Abstract. The rapid estimation of earthquake fatalities using earthquake parameters is the core basis for emergency response. However, there are numerous factors affecting earthquake fatalities, and it is impossible to obtain an accurate estimation result. The key to solve this problem is quantifying the uncertainty. In this paper, we proposed a new method to estimate earthquake fatalities and quantify the uncertainty based on basic earthquake emergency scenarios. The accuracy of the model is verified by earthquake that occurred during recent year. The preliminary analysis and comparison results show that the model is more effective and reasonable and can also provide a theoretical basis for post-earthquake emergency response.