As a consequence of climate change and human-induced land subsidence, coastal zones are directly impacted by sea-level rise. In some particular areas, the effects on the ecosystem and the urbanisation are particularly enhanced. We focus on the Emilia-Romagna coastal plain in Northern Italy, bounded by the Po river mouth to the north and by the Apennines to the south. The plain is ~ 130 km long and is characterised by wide areas below sea level, in part reclaimed wetlands. In this context, several morphodynamic factors make the shore and back-shore unstable. During next decades, the combined effects of land subsidence and of the sea-level rise in consequence of climate change are expected to enhance the shoreline instability, leading to a further retreat. The consequent loss of beaches would impact the economy of the region, tightly connected with tourism infrastructures. Furthermore, the loss of wetlands and dunes would threaten the ecosystem, crucial for the preservation of life and environment. These specific conditions show the importance of a precise definition of the possible local impacts of the ongoing and future climate variations. The aim of this work is the characterisation of vulnerability in different sectors of the coastal plain and the recognition of the areas in which human intervention is urgently required. The IPCC AR5 sea-level scenarios are merged with new high resolution terrain models, current data for local subsidence and predictions of a flooding model (<tt>in_CoastFlood</tt>) to develop different scenarios for the impact of sea-level rise to year 2100. First, the potential land loss due to the combined effect of subsidence and sea-level rise is extrapolated. Second, the increase of floodable areas in consequence of storm surges is quantitatively determined. The results are expected to support the regional mitigation and adaptation strategies designed in response to climate change.